Ֆարմացիայի ինստիտուտ
Institute of Pharmacy
In 2017 YSU Institute of Pharmacy with the mission of implementing educational, research and investment (innovation) functions was established.:
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Lusine H. Melkonyan

Candidate of Biology, Assistant | Chair of Pharmaceutical Chemistry and Pharmacognosy
Education
2000-2005 Armenian State Pedagogical University after Kh. Abovyan, Faculty of Biology and Chemistry, Department of Bio-ecology
2005-2009 Post-graduate student:Scientific and Production Center “Armbiotechnology” NAS RA

Academic degree, rank
PhD in Biology

Dissertation/thesis topic
“Obtaining of Highly Active Strain-producers of L-alanine and Development of Biosynthesis Technology”

Scope of scientific interests
Biotechnology, Microbiology, Genetics, Biochemistry

Lectures delivered
Biotechnology

Professional activities
2017 to present: Assistant at Chair of Pharmchemistry and Pharmacognosy of YSU Institute of Pharmacy
2017 to present: Senior researcher at the Scientific and Production Center “Armbiotechnology” NAS RA
2016: Assistant at Chair of Pharmchemistry and Pharmacognosy of Faculty of Pharmacy and Chemistry of Yerevan State University
2015-2016: Lecturer at Chair of Human and Animals Physiology of Faculty of Biology, Chemistry and Geography of Armenian State Pedagogical University after Kh. Abovyan
2014-2016: Researcher at the Scientific and Production Center “Armbiotechnology” NAS RA
2008-2013: Junior researcher at “Scientific Research Institute of Biotechnology” CJSC

Membership
Biotechnological Association of Armenia
Armenian Microbiological Association
Armenian Association of Biochemists
Federation of European Microbiological Societies (FEMS)
Federation of European Biochemical Societies (FEBS)

Awards/Honors
2009: First Mention Award (Young Knowledge Building the Futur, International Innovation Award 2009, Fruitfull Armenia 5th)

Grants/Contracts
465 “Improvement the Strain-Producer of L-Isoleucine Brevibacterium flavum 23 for Commercialization” (2008-2010)
ISTC #А-1868 “Development of the New Production Technology of Ecological Safe Complex Biofertilizer Based on Nitrogen-Fixing Microorganisms and Modified Zeolites” (2010-2012)
13-2I359 “Cloning of Genes of Alfa-Amylase and Glucoamylase of Technological Value and Characterization of Corresponding Enzymes” (2013-2015)
13RF-054 “Conceptually New Catalytic Systems Based on Chiral Cu(II), Ni(II), Pd(II) Complexes for Asymmetric C-C Bond Formation” (2013-2015)
#137270 “Short Term Conference and Travel Grant (Calouste Gulbenkian Foundation)” (2014)
690925 “Phoenix (H2020-MSCA-RISE-2015, HORIZON-2020)” (2015-2019)
16YR-2I016 “Obtaining Strain-Producer of ɑ-Amylase on the Basis of ɑ-Amylase Gene of Bacillus amyloliquifaciens and Characterization of the Recombinant Enzyme” (2016-2018)
#203719 “Short Term Conference and Travel Grant (Calouste Gulbenkian Foundation)” (2017)
“FEBS Bursary (Federation of European Biochemical Societies)” (2018)
21T-2I229 “Development of a New Multifunctional Biotechnological Preparation as a Biofertilizer, Biostimulant, Biopesticide” (2021-2024)
Lneg4 “BRISK2: TRANSNATIONAL ACCESS” (2022)

Secondments
2014: London (UK), December 13-19 (International Conference “Translational Biocatalysis”)
2017: Valencia (Spain), July 9-13 (7th Congress of European Microbiologists (FEMS))
2018: Prague (Czech Republic), July 7-14 (43rd FEBS Congress)
2018: Lisbon (Portugal), July 19 - August 21(LNEG – Laboratório Nacional de Energia e Geologia (National Laboratory of Energy and Geology, Lisbon, Portugal))
2019: Lisbon (Portugal), June 16 - August 18 (LNEG – Laboratório Nacional de Energia e Geologia (National Laboratory of Energy and Geology, Lisbon, Portugal))

Language skills
Armenian, Russian, English

E-mail address
lusinemelkonyan@ysu.am

Latest Publications (35)
L. Melkonyan , A. Toplaghaltsyan, S. Keleshyan, Zh. Karapetyan, G. Avetisova , G. Tsarukyan
Determination of Enzymatic Activity of Nitrogen-Fixing Bacteria Isolated from Saline Soils of Armenia
2021 | Thesis
International Scientific and Practical Conference “BIOTECHNOLOGY: Science and Practice. Innovation and Business”, October 20-22, 2021, Yerevan, Armenia, pp. 78-79
L. Melkonyan , G. Avetisova , G. Tsarukyan, S. Keleshyan, Zh. Karapetyan, A. Toplaghaltsyan, V. Ghochikyan
Influence of Vitamins on L-Tryptophan Production by Brevibacterium flavum
2021 | Article
International Scientific and Practical Conference “BIOTECHNOLOGY: Science and Practice. Innovation and Business”. October 20-22, 2021, Yerevan, Armenia, pp. 82-86
L. Melkonyan , G.Avetisova , A. Toplaghaltsyan, G. Tsarukyan, S. Keleshyan, Zh. Karapetyan, V. Ghochikyan
Co-cultivation of L-Tryptophan-producing Strain Brevibacterium flavum and Azotobacter vinelandii as an Alternative Method for Indole-3-Acetic Acid Production
2021 | Article
International Scientific and Practical Conference “BIOTECHNOLOGY: Science and Practice. Innovation and Business”. October 20-22, 2021, Yerevan, Armenia, pp. 6-10
L. Melkonyan , A. Ferreira, S. Carapinha, B. Ribeiro, D. Figueiredo, G. Avetisova , L. Gouveia
Biostimulant and biopesticide potential of microalgae growing in piggery wastewater
2021 | Article
Environmental Advances (Elsevier /Directory of Open Access Journals, DOAJ/), 2021, v. 4, 100062, doi.org/10.1016/j.envadv.2021.100062
L. Melkonyan , A. Ferreira, S. Carapinha, B. Ribeiro, D. Figueiredo, G. Avetisova , L. Gouveia
Assessment of biostimulant and biopesticide potential of microalgae following piggery wastewater treatment
2020 | Thesis
International Conference “AlgaEurope 2020”, December 01-04, 2020, ONLINE, pp. 17-19
L.H. Melkonyan , A.M. Paloyan, A.S. Sargsyan, A.V. Mkhitaryan, K.G. Dyukova, A.A. Hambardzumyan
Production and properties of a novel raw starch hydrolyzing α amylase from Bacillus amyloliquefaciens MDC1974
2020 | Article
Electronic Journal of Natural Sciences, 2020, v. 34, №1, pp. 4-11
L. Melkonyan , A. Paloyan, A. Mkhitaryan, K. Dyukova, A. Hambardzumyan
New α-amylase with potential to commercialize
2019 | Book
International Conference “Microbes: biology and application”. October 9-11, 2019, Yerevan, Armenia, p. 60
L.H. Melkonyan , A.M. Paloyan, A.V. Mkhitaryan, A.A. Hambardzumyan, G. Avetisova
New α-amylase from Bacillus sp. MDC 3500 strain
2019 | Thesis
Designer Biology 2019 conference “From proteins and cells to scaffolds & materials in Europe”. July 31- August 2, 2019, Newcastle, UK, p. 47
L. Melkonyan , S. Keleshyan, Zհ. Karapetyan, A. Toplaghaltsyan, G. Avetisova , G. Tsarukyan, V. Ghochikyan
Agrobacterium sp. as nitogen-fixing bacteria: effect of osmo-resistant strains on the growth of plants in saline soils of Armenia
2019 | Thesis
International Conference “Microbes: biology and application”. October 9-11, 2019, Yerevan, Armenia, pp. 31-32
L. Melkonyan , A. Ferreira, B. Ribeiro, M.L.A. Tavares, J. Vladic, S. Vidovic, D. Cvetkovic, G. Avetisova , V. Goginyan, L. Gouveia
Scenedesmus obliquus microalga-based biorefinery - from brewery effluent to bioactive compounds, biofuels and biofertilizers – aiming a circular bioeconomy
2019 | Article
Biofuels, Bioproducts and Biorefineries, 2019, v. 13, №5, pp.1169-1186, doi.org/10.1002/bbb.2032
Л.О. Мелконян , С.К. Келешян, Ж.В. Карапетян, А.Г. Топлакалцян, Г.Е. Аветисова , В.Т. Кочикян
Характеристика микрофлоры засоленных почв Армении
2019 | Article
Хранение и переработка сельхозсырья, 2019, №1, cc. 76-85, DOI: 10.36107/spfp.2019.81
L. Melkonyan , A. Ferreira, A. Reis, S. Vidovic, J. Vladic, S. Gkelis, G. Avetisova , R. Congestri, G. Acién, R. Muñoz, P. Collet, L. Gouveia
Combining Microalgae-Based Wastewater Treatment with Biofuel and Bio-Based Production in the Frame of a Biorefinery. In: Hallmann A., Rampelotto P. (eds) Grand Challenges in Algae Biotechnology
2019 | Book
Grand Challenges in Biology and Biotechnology. Springer, Cham, 2019, pp 319-369, DOI:10.1007/978-3-030-25233-5_9 (ISBN 978-3-030-25232-8; ISBN 978-3-030-25233-5 /eBook/)
A. Ferreira, B. Ribeiro, J. Vladic, S. Vidovic, D. Cvetkovic, L. Melkonyan , G. Avetisova , AF. Ferreira, M. Costa, A. Reis, L. Gouveia
Industrial wastewater-grown Scenedesmus obliquus biomass-to-fuels and biofertilizers production: an integrative approach
2019 | Thesis
IWA Conference on Algal Technologies and Stabilization Ponds for Wastewater Treatment and Resource Recovery (IWAlgae2019), July 1-2, 2019, Valladolid, Spain, 2.B.8.
A. Ferreira, S. Carapinha, J. Vladic, S. Vidovic, D. Cvetkovic, L. Melkonyan , G. Avetisova , L. Gouveia
Tiny Microalgae For Huge Applications. Biorefinery Approach
2019 | Thesis
1st International Conference on Advanced Production and Processing, October 10-11, 2019, Novi Sad, Serbia. p. 251
L. Melkonyan , A. Toplaghaltsyan, S. Keleshyan, Z. Karapetyan, G. Avetisova, A. Vardanyan
Optimization of fermentation conditions for histidine producers resistant to non-protein amino acids
2018 | Thesis
1st International Scientific Conference “Currents state of pharmacy and prospects of its development”, November 1-3, 2018, Yerevan, Armenia. p. 101
L. Melkonyan , G. Avetisova, A. Paloyan, V. Ghochikyan, A. Tsaturyan, S. Keleshyan, Z. Karapetyan, A. Toplaghaltsyan
Study of synthesis of amino acids by Azotobacter vinilandii AV1 strain
2018 | Thesis
1st International Scientific Conference “Currents state of pharmacy and prospects of its development”, November 1-3, 2018, Yerevan, Armenia. pp. 77-78
L. Melkonyan , A. Paloyan, A. Hambardzumyan, G. Avetisova , A. Mkhitaryan, A. Sargsyan, S. Stepanyan, S. Arabachyan, A. Saghyan
Study of some metals effect on a-amylase activity of Bacillus amyloliquefaciens MDC 1974 strain
2018 | Thesis
43rd FEBS Congress. July 7-12, 2018, Prague, Czech Republic, FEBS Open Bio 8 (Suppl.S1) p.178, DOI: 10.1002/2211-5463.12453
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L. Melkonyan , A. Paloyan, A. Sargsyan, T. Arakelyan, M. Izmailyan, G. Avetisova , A. Hambardzumyan, A. Saghyan
Optimization of fermentation condition for a-amylase production
2018 | Thesis
43rd FEBS Congress. July 7-12, 2018, Prague, Czech Republic, FEBS Open Bio 8 (Suppl.S1) p. 177, DOI: 10.1002/2211-5463.12453
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L. Melkonyan , G. Avetisova , A. Chakhalyan, S. Keleshyan, Zh. Karapetyan, S. Stepanyan, A. Toplaghaltsyan, A. Saghyan
Biotechnological approaches for obtaining of new complex biopreparation for organic agriculture
2017 | Thesis
7th Congress of European Microbiologists (FEMS). July 9-13, 2017, Valencia, Spain, 337
К. М. Сарикян, Г. Ж. Саргсян, Г. Е. Аветисова , Л. О. Мелконян
Новое биоудобрение «Азоцеовит-1» для органического овощеводства и его испытание на посадках перца и баклажана в Армении
2017 | Article
ІІІ Международная научно-практическая конференция «Неделя науки в Крутах – 2017». 13-14 марта, 2017, Круты, Черниговская обл., Украина, 264-271
A. Toplaghaltsyan, S. Keleshyan, Zh. Karapetyan, N. Khachaturian, G. Avetisova , L. Melkonyan , S. Stepanyan
Screening of lactic acid bacteria with a wide spectrum of antifungal activity
2017 | Thesis
4th International Scientific Conference of Young Researchers “Biotechnology: Science and Practice”. 2017, 66-67 pp.
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G. Avetisova , L. Melkonyan , S. Stepanyan, K. Sarikyan, V. Ghochikyan, S. Keleshyan, Zh. Karapetyan, A. Toplaghaltsyan
Effect of " Ecobiofeed+ " Biopreparation on Eggplant (Solanum Melongena S.)
2017 | Thesis
4th International Scientific Conference of Young Researchers “Biotechnology: Science and Practice”. 2017, p. 63
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L. Melkonyan , A. Paloyan, A. Sargsyan, A. Mkhitaryan, A. Hambardzumyan
Substrate specifity of x-amylase isolated from B.amiloliquefaciens strain MDC1974
2017 | Thesis
4th International Scientific Conference of Young Researchers “Biotechnology: Science and Practice”. September 28-30, 2017, Yerevan, Armenia, pp. 37-38
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Мелконян Л. О. , Степанян С. Х., Аветисова Г. Е. , Сарикян К. М.
Новый биопрепарат «экобиофид+» для органического земледелия и его испытание на посадках томатов в Армении
2017 | Article
Innovative approaches and perspective ideas of young scientists in agrarian sciences. The proceedings of the international scientific-practical conference of young scientist. 2017, 384-387pp.
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К. М. Сарикян, Г. Ж. Саргсян, Г. Е. Аветисова , Л. О. Мелконян
Новое биоудобрение «Азоцеовит-1» для органического овощеводства и его испытание на посадках перца и баклажана в Армении
2017 | Article
Неделя науки в Крутах -2017. 2, стр. 264-271
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А. Х. Чахалян, С. К. Келешян, Ж. В. Карапетян, А. Г. Давтян, Г. Е. Аветисова , Л. О. Мелконян , А. С. Дадаян, А. С. Сагиян
Изучение ингибирующих свойств новых небелковых аминокислот и отбор эффективных аналогов L-аминокислот для селекции высокоактивных штаммов-продуцентов
2016 | Article
Прикладная биохимия и микробиология (Applied Biochemistry and Microbiology), 2016, 52, стр. 62–67
L. H. Melkonyan , G. H. Tepanosyan, G. Ye. Avetisova , A. Kh. Chakhalyan, S. Gh. Keleshyan, Zh. V. Karapetyan
The nitrogen-fixing strain for biopreparation
2016 | Article
Biological Journal of Armenia, 2016, 68, pp. 65-68
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Chakhalyan A. Kh., Keleshyan S. Gh., Karapetyan Zh. V., Davtyan A. G., Avetisova G. Y. , Melkonyan L. H. , Dadayan A. S. , Saghyan A. S.
The inhibitory properties of new non-protein amino acids and the screening of effective analogs of L-amino acids for the selection of highly active strain-producers
2016 | Article
Applied Biochemistry and Microbiology, 2016, v. 52, № 1, p. 51-55
G. Ye. Avetisova, L. H. Melkonyan , A. Kh. Chakhalyan, S. Gh. Keleshyan, Zh. V. Karapetyan, A. S. Saghyan
New complex nitrogen biofertilizer for agriculture
2014 | Thesis
International Conference “Translational Biocatalysis”. December 16, 2014, RSC, Burlington House, London, UK. p. 12
G. Ye. Avetisova , L. H. Melkonyan , A. Kh. Chakhalyan, S. Gh. Keleshyan, A. S. Saghyan
Selection of new highly active L-alanine producer strains of Brevibacterium flavum and comparison of their activity in alanine synthesis
2014 | Article
Russian Journal of Genetics: Applied Research, 2014, 4, 1, 23-26
Селекция новых высокоактивных штаммов–продуцентов L–аланина у Brevibacterium flavum и сравнительная характеристика их аланинcинтезирующей активности
2013 | Article
Вавиловский журнал генетики и селекции, 2013, 17, 3, 430–434
Л. О. Мелконян , А. А. Амбарцумян, Г. Е. Аветисова , А. Х. Чахалян, А. С. Сагиян
Показатели материально-энергетического баланса биосинтеза L-аланина Brevibacterium flavum
2013 | Article
Биотехнология, 2013, 3, 47-50
Study of regulation of some key enzymes of L-alanine biosynthesis by Brevibacterium flavum producer strains
2013 | Article
Applied Biochemistry and Microbiology, 2013, 49, 2, 120-124
L-ալանինի ստացման եղանակ
2012 | Patent
ՀՀ Արտոնագիր №2691A, 2012
A. Chakhalyan, G. Avetisova , A. Saghiyan , L. Chil-Akopyan, L. Melkonyan , R. Gevorkyan, H. Sargsyan, L. Ghazarian
Zeolites in complex nitrogen biofertilizers
2008 | Article
ELSEVIER, Zeolites and related materials – trends, targets and challenges, 2008, 521-524